Jmaqintf tomic for

نویسنده

  • Eric Henderson
چکیده

The atomic force microscope (AFM) was used to image supercooled plasm id DNA deposited on a mica surface in either a foydrated or desiccated state. Hydrated plasmid was precisely cut by the scanning tip at a location determined by the instrument operator. Small pieces of ON A (100-150 mm in length) were excised and deposited adjacent to the dissected plasmid, demonstrating that it is possible to remove and manipulate genomic DNA fragments, unresolvable by light microscopy, from defined chromosomal locations by AFM.

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تاریخ انتشار 2005